Phosphodiesterase 4D, cAMP Specific (PDE4D) Antibody

PDE4D Antibody is a Rabbit Polyclonal antibody against PDE4D. PDE4D(cAMP-specific 3',5'-cyclic phosphodiesterase 4D) is also named as DPDE3, PDE43 and belongs to the cyclic nucleotide phosphodiesterase family and PDE4 subfamily. PDE4D subtype may be of particular importance as an antidepressant target in that it is regulated by repeated treatment with both norepinephrine and serotonin reuptake inhibitors as well as by the PDE4 inhibitor rolipram(PMID:16730340). It has at least 9 isoforms and all 9 PDE4D isoforms are expressed in healthy adult human hippocampus and in hippocampus from a patient with advanced Alzheimer disease(PMID:17353396). This antibody is specific to PDE4D.

Target	Phosphodiesterase 4D, cAMP Specific (PDE4D)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 249-518 of human PDE4D.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q08499 (UniProt, ExPASy)
UniProt Entry Name	PDE4D_HUMAN
Gene Symbol	PDE4D
GeneID	5144
NCBI Accession	NP_001184152.1
KEGG	hsa:5144
String	9606.ENSP00000345502
Molecular Weight	Calculated MW: 91 kDa Observed MW: 91 kDa, 105 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Phosphodiesterase 4D, cAMP Specific (PDE4D)

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