Phosphodiesterase 4D, cAMP Specific (PDE4D) Antibody

Catalogue No: abx001394
Price: £120.00
(Size: 20 µl)
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PDE4D Antibody is a Rabbit Polyclonal antibody against PDE4D. PDE4D(cAMP-specific 3',5'-cyclic phosphodiesterase 4D) is also named as DPDE3, PDE43 and belongs to the cyclic nucleotide phosphodiesterase family and PDE4 subfamily. PDE4D subtype may be of particular importance as an antidepressant target in that it is regulated by repeated treatment with both norepinephrine and serotonin reuptake inhibitors as well as by the PDE4 inhibitor rolipram(PMID:16730340). It has at least 9 isoforms and all 9 PDE4D isoforms are expressed in healthy adult human hippocampus and in hippocampus from a patient with advanced Alzheimer disease(PMID:17353396). This antibody is specific to PDE4D.

Target PDE4D
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human PDE4D.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q08499 (UniProt, ExPASy)
UniProt Entry Name PDE4D_HUMAN
Gene Symbol PDE4D
GeneID 5144
KEGG hsa:5144
String 9606.ENSP00000345502
Molecular Weight Calculated MW: 23-24 kDa, 57-91 kDa
Observed MW: 91 kDa, 105 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on PDE4D

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