Platelet Derived Growth Factor Receptor Beta (PDGFRB) Antibody

PDGFRB Antibody is a Rabbit Polyclonal antibody against PDGFRB. This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

Target	Platelet Derived Growth Factor Receptor Beta (PDGFRB)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PDGFRB.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P09619 (UniProt, ExPASy)
UniProt Secondary AC	B5A957, Q8N5L4
UniProt Entry Name	PGFRB_HUMAN
Gene Symbol	PDGFRB
GeneID	5159
NCBI Accession	NP_002600.1
KEGG	hsa:5159
String	9606.ENSP00000261799
Molecular Weight	Calculated MW: 124 kDa Observed MW: 200 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Platelet Derived Growth Factor Receptor Beta (PDGFRB)

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