Pyruvate Dehydrogenase E1 Component Subunit Alpha, Somatic Form, Mitochondrial (PDHA1) Antibody

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Catalogue No: abx001554
Price: US$203.00
(Size: 20 µl)

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Datasheet SDS
PDHA1 Antibody is a Rabbit Polyclonal antibody against PDHA1. The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target Pyruvate Dehydrogenase E1 Component Subunit Alpha, Somatic Form, Mitochondrial (PDHA1)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC, IP
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, IP: 1/20 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 30-390 of human PDHA1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P08559 (UniProt, ExPASy)
UniProt Entry Name ODPA_HUMAN
Gene Symbol PDHA1
GeneID 5160
NCBI Accession NP_000275.1
KEGG hsa:5160
String 9606.ENSP00000369134
Molecular Weight Calculated MW: 43 kDa
Observed MW: 43 kDa
Buffer PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Pyruvate Dehydrogenase E1 Component Subunit Alpha, Somatic Form, Mitochondrial (PDHA1)


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