Pyruvate Dehydrogenase E1 Component Subunit Alpha, Somatic Form, Mitochondrial (PDHA1) Antibody
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Catalogue No: abx001554
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US$348.00
(Size: 60 µl)
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Datasheet SDS
PDHA1 Antibody is a Rabbit Polyclonal antibody against PDHA1. The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Research Articles on Pyruvate Dehydrogenase E1 Component Subunit Alpha, Somatic Form, Mitochondrial (PDHA1)
| Target | Pyruvate Dehydrogenase E1 Component Subunit Alpha, Somatic Form, Mitochondrial (PDHA1) |
| Research Area | Enzymes and Kinases, Metabolism |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human PDHA1 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P08559 (UniProt, ExPASy) |
| UniProt Entry Name | ODPA_HUMAN |
| Gene Symbol | PDHA1 |
| GeneID | 5160 |
| NCBI Accession | NP_000275.1 |
| KEGG | hsa:5160 |
| String | 9606.ENSP00000369134 |
| Molecular Weight | Calculated MW: 40 kDa/43 kDa/44 kDa/47 kDa Observed MW: 45 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
