Pancreas/duodenum Homeobox Protein 1 (PDX1) Antibody

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2.The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression.Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

Target	Pancreas/duodenum Homeobox Protein 1 (PDX1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human PDX1 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P52945 (UniProt, ExPASy)
UniProt Secondary AC	O60594, Q5VYW2
UniProt Entry Name	PDX1_HUMAN
Gene Symbol	PDX1
GeneID	3651
OMIM	125853
HGNC	6107
KEGG	hsa:3651
Ensembl	ENSG00000139515
String	9606.ENSP00000370421
Molecular Weight	30.8 kDa
Buffer	PBS, containing 0.05% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Pancreas/duodenum Homeobox Protein 1 (PDX1)

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