Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARGC1A) Antibody

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPAR gamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

Target	Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARGC1A)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA
Host	Mouse
Recommended dilutions	ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human PGC-1alpha expressed in E. coli.
Isotype	IgG2b
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9UBK2 (UniProt, ExPASy)
UniProt Entry Name	PRGC1_HUMAN
Gene Symbol	PPARGC1A
GeneID	10891
OMIM	604517
HGNC	9237
Ensembl	ENSG00000109819
String	9606.ENSP00000264867
Molecular Weight	91 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARGC1A)

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