Pepsin A-5 (PGA5) Antibody
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Price:
US$420.50
(Size: 100 µl)
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PGA5: Pepsinogen 5, group I (pepsinogen A).Pepsinogens are the inactive precursors of pepsin, the major acid protease found in the stomach.Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa.Pepsin consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41 amino acid segment from the N-terminus.Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity (pH 1-3) for pepsin function.Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids.Pepsin shows extremely broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.PGA5 is a member of the subfamily A1 within the pepsin family and is the predominant endopeptidase in the gastric juice of vertebrates.PGA5 is inhibited by ovUS-1, a uterine serpin.
Target |
Pepsin A-5 (PGA5) |
Clonality |
Monoclonal |
Reactivity |
Human |
Tested Applications |
ELISA, WB, IHC |
Host |
Mouse |
Recommended dilutions |
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
Purified recombinant fragment of human PGA5 expressed in E. coli. |
Isotype |
IgG1 |
Form |
Liquid |
Purification |
Unpurified ascites. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC |
P0DJD9 (UniProt,
ExPASy)
|
UniProt Secondary AC |
A8K749, B7ZW62, B7ZW75, P00790, Q7M4R0, Q8N1E3 |
Gene Symbol |
PGA5 |
GeneID |
5222
|
OMIM |
169700
|
HGNC |
8887
|
Ensembl |
ENSG00000256713 |
Molecular Weight |
42 kDa |
Buffer |
Ascitic fluid containing 0.03% sodium azide. |
Concentration |
Not determined. |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |
Research Articles on Pepsin A-5 (PGA5)