Pepsinogen C (PGC) Antibody

Pepsinogen C Antibody is a Rabbit Polyclonal antibody against Pepsinogen C. This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.

Target	Pepsinogen C (PGC)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/100 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 73-172 of human Pepsinogen II (PG II).
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P20142 (UniProt, ExPASy)
UniProt Secondary AC	B4DVZ3, Q5T3D7, Q5T3D8
Gene Symbol	PGC
GeneID	5225
NCBI Accession	NP_001159896.1
Molecular Weight	Calculated MW: 42 kDa Observed MW: 45-50 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	1.69 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Pepsinogen C (PGC)

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