Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatase 1 (INPP5D) Antibody

Catalogue No: abx000561
Price: £120.00
(Size: 20 µl)
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Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatase 1 (INPP5D) Antibody

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INPP5D Antibody is a Rabbit Polyclonal antibody against INPP5D. INPP5D, also named as SHIP, SHIP1, SIP-145 and hp51CN, belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family. INPP5D is phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. INPP5D acts as a negative regulator of B-cell antigen receptor signaling. It mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. INPP5D acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. INPP5D regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. It is involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. It is a key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. It modulates FCGR3/CD16-mediated cytotoxicity in NK cells. It mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. INPP5D may also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.

Target INPP5D
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human INPP5D.
Isotype IgG
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q92835 (UniProt, ExPASy)
UniProt Secondary AC O00145, Q13544, Q13545, Q6P5A4, Q92656, Q9UE80
UniProt Entry Name SHIP1_HUMAN
Gene Symbol INPP5D
GeneID 3635
KEGG hsa:3635
String 9606.ENSP00000405338
Molecular Weight 133 kDa
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatase 1 (INPP5D) Antibody

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