E3 SUMO-Protein Ligase PIAS4 (PIAS4) Antibody
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Catalogue No: abx026852
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US$326.25
(Size: 80 µl)
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Datasheet SDS
PIASy1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway, the wnt pathway and the steroid hormone signaling pathway. PIASy1 is involved in gene silencing, and promotes PARK7 sumoylation.
Research Articles on E3 SUMO-Protein Ligase PIAS4 (PIAS4)
| Target | E3 SUMO-Protein Ligase PIAS4 (PIAS4) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 48-79 amino acids from the N-terminal region of human PIASy. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q8N2W9 (UniProt, ExPASy) |
| UniProt Secondary AC | O75926, Q96G19, Q9UN16 |
| UniProt Entry Name | PIAS4_HUMAN |
| NCBI Accession | NP_056981.2 |
| KEGG | hsa:51588 |
| String | 9606.ENSP00000262971 |
| Molecular Weight | Calculated MW: 56.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |