Protein Interacting With Protein Kinase C Alpha 1 (PICK1) Antibody
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Catalogue No: abx001280
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(Size: 60 µl)
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Datasheet SDS
PICK1 Antibody is a Rabbit Polyclonal antibody against PICK1. Protein interacting with C kinase 1 (PICK1) is a PDZ-domain containing protein that is located in the perinuclear region and is phosphorylated in response to PKCå activation. PKCå, which is essential for the regulation of proliferation and differentiation in numerous cell types, contains within its catalytic region a PDZ-binding domain that is absent from other PKC isoforms. Mutation of the PICK1 PDZ domain inhibits the binding of PICK1 to PKCå. PICK1 also interacts with the carboxy terminus of a-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor, a neurotransmitter receptor located at excitatory synapses, suggesting that PICK1 plays a role in the modulation of synaptic transmission by targeting and anchoring AMPA to specific synapses.
Research Articles on Protein Interacting With Protein Kinase C Alpha 1 (PICK1)
| Target | Protein Interacting With Protein Kinase C Alpha 1 (PICK1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | IHC |
| Host | Rabbit |
| Recommended dilutions | IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to human PICK1 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q9NRD5 (UniProt, ExPASy) |
| UniProt Secondary AC | B3KS52, O95906 |
| UniProt Entry Name | PICK1_HUMAN |
| Gene Symbol | PICK1 |
| GeneID | 9463 |
| NCBI Accession | NP_036539.1 |
| String | 9606.ENSP00000385205 |
| Molecular Weight | Calculated MW: 39 kDa/46 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
