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Protein Interacting With Protein Kinase C Alpha 1 (PICK1) Antibody

Catalogue No: abx001280
Price: £120.00
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PICK1 Antibody is a Rabbit Polyclonal antibody against PICK1. Protein interacting with C kinase 1 (PICK1) is a PDZ-domain containing protein that is located in the perinuclear region and is phosphorylated in response to PKCå activation. PKCå, which is essential for the regulation of proliferation and differentiation in numerous cell types, contains within its catalytic region a PDZ-binding domain that is absent from other PKC isoforms. Mutation of the PICK1 PDZ domain inhibits the binding of PICK1 to PKCå. PICK1 also interacts with the carboxy terminus of a-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor, a neurotransmitter receptor located at excitatory synapses, suggesting that PICK1 plays a role in the modulation of synaptic transmission by targeting and anchoring AMPA to specific synapses.

Target PICK1
Clonality Polyclonal
Reactivity Human
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human PICK1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9NRD5 (UniProt, ExPASy)
UniProt Secondary AC B3KS52, O95906
UniProt Entry Name PICK1_HUMAN
Gene Symbol PICK1
GeneID 9463
String 9606.ENSP00000385205
Molecular Weight Calculated MW: 39 kDa, 46 kDa
Observed MW: 53 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Protein Interacting With Protein Kinase C Alpha 1 (PICK1) Antibody

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