PIK3R1/2/3 (pY467) Antibody

Catalogue No: abx000474
Price: £220.00
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PIK3R1/2/3 (pY467) Antibody

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PIK3R1/2/3 (pY467) Antibody is a Rabbit Polyclonal antibody against PIK3R1/2/3 (pY467). Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1./Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.

Target PIK3R1/2/3 (pY467)
Reactivity Human, Mouse, Rat
Origin Human
Host Rabbit
Clonality Polyclonal
Tested Applications WB
Recommended dilutions WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y467 of human PIK3R1/2/3.
Purification Affinity purified.
Isotype IgG
Conjugation Unconjugated
Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight 85 kDa
Swiss Prot P27986 Q92569 O00459
GeneID 5295/ 8503/ 5296
Gene Symbol PIK3R1, PIK3R2, PIK3R3
Concentration > 1 mg/ml
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Availability Shipped within 5-10 working days.
Note This product is for research use only.

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