PIK3R1 / 2 / 3 (pY467) Antibody
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Catalogue No: abx000474
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US$232.00
(Size: 20 µl)
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Datasheet SDS
PIK3R1/2/3 (pY467) Antibody is a Rabbit Polyclonal antibody against PIK3R1/2/3 (pY467). Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1./Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
Research Articles on PIK3R1/2/3 (pY467)
| Target | PIK3R1/2/3 (pY467) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A phospho specific peptide corresponding to residues surrounding Y467 of human PIK3R1/2/3 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P27986 (UniProt, ExPASy) Q92569 (UniProt, ExPASy) O00459 (UniProt, ExPASy) |
| Gene Symbol | PIK3R1, PIK3R2, PIK3R3 |
| GeneID | 5295/ 8503/ 5296 |
| Molecular Weight | Calculated MW: 42-54 kDa/81-84 kDa Observed MW: 85 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |