PIK3R1 / 2 / 3 (pY467) Antibody

PIK3R1/2/3 (pY467) Antibody is a Rabbit Polyclonal antibody against PIK3R1/2/3 (pY467). Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1./Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.

Target	PIK3R1/2/3 (pY467)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A phospho specific peptide corresponding to residues surrounding Y467 of human PIK3R1/2/3
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P27986 (UniProt, ExPASy) Q92569 (UniProt, ExPASy) O00459 (UniProt, ExPASy)
Gene Symbol	PIK3R1, PIK3R2, PIK3R3
GeneID	5295/ 8503/ 5296
Molecular Weight	Calculated MW: 42-54 kDa/81-84 kDa Observed MW: 85 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on PIK3R1/2/3 (pY467)

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