Piwi Like RNA-Mediated Gene Silencing 4 (PIWIL4) Antibody

PIWIL4 Antibody is a Rabbit Polyclonal antibody against PIWIL4. PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells. Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association.

Target	Piwi Like RNA-Mediated Gene Silencing 4 (PIWIL4)
Clonality	Polyclonal
Reactivity	Human, Rat
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant protein of human PIWIL4
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q7Z3Z4 (UniProt, ExPASy)
UniProt Secondary AC	B4DEG5, Q68CZ4, Q8N8G9, Q8N9V8, Q8NEH2
UniProt Entry Name	PIWL4_HUMAN
Gene Symbol	PIWIL4
GeneID	143689
KEGG	hsa:143689
String	9606.ENSP00000299001
Molecular Weight	Calculated MW: 97 kDa Observed MW: 97 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Piwi Like RNA-Mediated Gene Silencing 4 (PIWIL4)

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