PKCz Antibody is a Rabbit Polyclonal antibody against PKCz. Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.

Target	Protein Kinase C Zeta Type (PRKCZ)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein corresponding to human PKC zeta
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Shelf Life	12 months.
UniProt Primary AC	Q05513 (UniProt, ExPASy)
UniProt Secondary AC	A8K4N0, A8MU64, B7Z2J7, E9PCW2, Q15207, Q5SYT5, Q969S4
UniProt Entry Name	KPCZ_HUMAN
Gene Symbol	PRKCZ
GeneID	5590
NCBI Accession	NP_002735.3
KEGG	hsa:5590
String	9606.ENSP00000367830
Molecular Weight	Calculated MW: 46 kDa/56 kDa/67 kDa Observed MW: 70 kDa
Buffer	PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Research Articles on Protein Kinase C Zeta Type (PRKCZ)

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