Pyruvate Kinase, Liver And RBC (PKLR) Antibody

PKLR Antibody is a Rabbit Polyclonal antibody against PKLR. The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.

Target	Pyruvate Kinase, Liver And RBC (PKLR)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 375-574 of human PKLR.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P30613 (UniProt, ExPASy)
UniProt Secondary AC	O75758, P11973
UniProt Entry Name	KPYR_HUMAN
Gene Symbol	PKLR
GeneID	5313
NCBI Accession	NP_000289.1
KEGG	hsa:5313
String	9606.ENSP00000339933
Molecular Weight	Calculated MW: 62 kDa Observed MW: 62 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Pyruvate Kinase, Liver And RBC (PKLR)

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