Urokinase-Type Plasminogen Activator (PLAU) Antibody

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Catalogue No: abx001793
Price: US$203.00
(Size: 20 µl)

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Datasheet SDS
PLAU Antibody is a Rabbit Polyclonal antibody against PLAU. This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target Urokinase-Type Plasminogen Activator (PLAU)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 20-180 of human PLAU.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P00749 (UniProt, ExPASy)
UniProt Secondary AC B4DPZ2, Q15844, Q16618, Q53XS3, Q5SWW9, Q969W6
UniProt Entry Name UROK_HUMAN
Gene Symbol PLAU
GeneID 5328
NCBI Accession NP_002649.1
KEGG hsa:5328
String 9606.ENSP00000361850
Molecular Weight Calculated MW: 49 kDa
Observed MW: 49 kDa
Buffer PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Urokinase-Type Plasminogen Activator (PLAU)


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