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Urokinase-Type Plasminogen Activator (PLAU) Antibody

Catalogue No: abx001793
Price: £120.00
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Urokinase-Type Plasminogen Activator (PLAU) Antibody

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PLAU Antibody is a Rabbit Polyclonal antibody against PLAU. This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target PLAU
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human PLAU.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P00749 (UniProt, ExPASy)
UniProt Secondary AC B4DPZ2, Q15844, Q16618, Q53XS3, Q5SWW9, Q969W6
UniProt Entry Name UROK_HUMAN
Gene Symbol PLAU
GeneID 5328
KEGG hsa:5328
String 9606.ENSP00000361850
Molecular Weight Calculated MW: 46 kDa, 48 kDa
Observed MW: 45 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Urokinase-Type Plasminogen Activator (PLAU) Antibody

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