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Urokinase Plasminogen Activator Surface Receptor / uPAR / CD87 (PLAUR) Antibody

Catalogue No: abx001219
Price: £120.00
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Urokinase Plasminogen Activator Surface Receptor / uPAR / CD87 (PLAUR) Antibody

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PLAUR Antibody is a Rabbit Polyclonal antibody against PLAUR. Urokinase plasminogen activator surface receptor (uPAR, also known as PLAUR or CD87) is a 45-65 kDa, highly glycosylated, GPI-anchored membrane protein. It contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, urokinase plasminogen activator (uPA) cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559).

Target Urokinase Plasminogen Activator Surface Receptor / uPAR / CD87 (PLAUR)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human PLAUR.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q03405 (UniProt, ExPASy)
Gene Symbol PLAUR
GeneID 5329
Molecular Weight Calculated MW: 31 kDa, 32 kDa, 36 kDa
Observed MW: 74 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Urokinase Plasminogen Activator Surface Receptor / uPAR / CD87 (PLAUR) Antibody

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