PLCG1 (pY783) Antibody

PLCG1 (pY783) Antibody is a Rabbit Polyclonal antibody against PLCG1 (pY783). The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.

Target	PLCG1 (pY783)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic phosphorylated peptide around Y783 of human PLC gamma 1 (PLCG1).
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P19174 (UniProt, ExPASy)
UniProt Secondary AC	B7ZLY7, B9EGH4, E1P5W4, Q2V575
UniProt Entry Name	PLCG1_HUMAN
Gene Symbol	PLCG1
GeneID	5335
NCBI Accession	NP_877963.1
KEGG	hsa:5335
String	9606.ENSP00000244007
Molecular Weight	Calculated MW: 149 kDa Observed MW: 155 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on PLCG1 (pY783)

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