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DNA Polymerase Eta (POLH) Antibody

Catalogue No: abx001515
Price: £120.00
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DNA Polymerase Eta (POLH) Antibody DNA Polymerase Eta (POLH) Antibody DNA Polymerase Eta (POLH) Antibody

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POLH Antibody is a Rabbit Polyclonal antibody against POLH. This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. [provided by RefSeq, Jul 2008].

Target POLH
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human POLH.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9Y253 (UniProt, ExPASy)
UniProt Secondary AC Q7L8E3, Q96BC4, Q9BX13
UniProt Entry Name POLH_HUMAN
Gene Symbol POLH
GeneID 5429
String 9606.ENSP00000361310
Molecular Weight Calculated MW: 46 kDa, 78 kDa
Observed MW: 70 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on DNA Polymerase Eta (POLH) Antibody

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