Poly ADP-Ribose Polymerase 1 (PARP1) Antibody

Poly ADP-Ribose Polymerase 1 (PARP1) Antibody is a Mouse Monoclonal antibody for the detection of PARP1.

PARP1 (poly (ADP-ribose) polymerase 1) is a nuclear enzyme catalyzing the poly (ADP-ribosyl) ation of many key proteins in vivo. The normal function of PARP1 is the routine repair of DNA damage. Activated by DNA strand breaks, the PARP1 is cleaved into an 85 to 89-kDa COOH-terminal fragment and a 24-kDa NH2-terminal peptide by caspases during the apoptotic process. The appearance of PARP fragments is commonly considered as an important biomarker of apoptosis.

Target	Poly ADP-Ribose Polymerase 1 (PARP1)
Clonality	Monoclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Mouse
Recommended dilutions	WB: 1/5000 - 1/30000, IHC: 1/100 - 1/1000, IF/ICC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	poly (ADP-ribose) polymerase 1
Isotype	IgG1
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by Protein A and Protein G affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P09874 (UniProt, ExPASy)
UniProt Secondary AC	B1ANJ4, Q8IUZ9
UniProt Entry Name	PARP1_HUMAN
Gene Symbol	PARP1
GeneID	142
OMIM	173870
HGNC	270
KEGG	hsa:142
Ensembl	ENSG00000143799
String	9606.ENSP00000355759
Molecular Weight	Observed MW: 115 kDa, 89 kDa
Buffer	0.01 M PBS, pH 7.4.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Poly ADP-Ribose Polymerase 1 (PARP1)

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