Adrenocorticotropic Hormone (ACTH) Antibody

Adrenocorticotropic Hormone Antibody is a Rabbit Polyclonal antibody against Adrenocorticotropic Hormone. This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation.

Target	Adrenocorticotropic Hormone (ACTH)
Clonality	Polyclonal
Reactivity	Human, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human POMC.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P01189 (UniProt, ExPASy)
UniProt Secondary AC	P78442, Q53T23, Q9UD39, Q9UD40
UniProt Entry Name	COLI_HUMAN
Gene Symbol	POMC
GeneID	5443
NCBI Accession	NP_000930.1
KEGG	hsa:5443
String	9606.ENSP00000384092
Molecular Weight	Calculated MW: 29 kDa Observed MW: 35 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Adrenocorticotropic Hormone (ACTH)

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