Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) Antibody

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Target	Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 355-382 amino acids from human PPM1A.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P35813 (UniProt, ExPASy)
UniProt Secondary AC	B5BU11, J3KNM0, O75551
Gene Symbol	PPM1A
Molecular Weight	Calculated MW: 42.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow and Rabbit PPM1A.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A)

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