Protein Phosphatase, Mg2+/Mn2+ Dependent 1F (PPM1F) Antibody
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Catalogue No: abx031314
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US$326.25
(Size: 80 µl)
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Datasheet SDS
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.
Research Articles on Protein Phosphatase, Mg2+/Mn2+ Dependent 1F (PPM1F)
| Target | Protein Phosphatase, Mg2+/Mn2+ Dependent 1F (PPM1F) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 275-303 amino acids from the Central region of human PPM1F. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P49593 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K6G3, B7Z2C3, Q96PM2 |
| UniProt Entry Name | PPM1F_HUMAN |
| KEGG | hsa:9647 |
| String | 9606.ENSP00000263212 |
| Molecular Weight | Calculated MW: 49.8 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |