Serine/threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit (PPP1CA) Antibody
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Catalogue No: abx011880
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US$427.75
(Size: 100 µl)
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Datasheet SDS
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Research Articles on Serine/threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit (PPP1CA)
| Target | Serine/threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit (PPP1CA) |
| Research Area | Enzymes and Kinases |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human PPP1CA expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P62136 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NNR3, B2R908, P08129, P20653, P22802, Q07161 |
| UniProt Entry Name | PP1A_HUMAN |
| Gene Symbol | PPP1CA |
| GeneID | 5499 |
| OMIM | 176875 |
| HGNC | 9281 |
| KEGG | hsa:5499 |
| Ensembl | ENSG00000172531 |
| String | 9606.ENSP00000326031 |
| Enzyme Commission Number | EC 3.1.3.16 |
| Molecular Weight | 38 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |