Serine/threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit (PPP1CA) Antibody

PPP1CA Antibody is a Rabbit Polyclonal antibody against PPP1CA. The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target	Serine/threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit (PPP1CA)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-330 of human PPP1CA.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P62136 (UniProt, ExPASy)
UniProt Secondary AC	A6NNR3, B2R908, P08129, P20653, P22802, Q07161
UniProt Entry Name	PP1A_HUMAN
Gene Symbol	PPP1CA
GeneID	5499
NCBI Accession	NP_002699.1
KEGG	hsa:5499
String	9606.ENSP00000326031
Molecular Weight	Calculated MW: 38 kDa Observed MW: 38 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Serine/threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit (PPP1CA)

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