Prolylcarboxypeptidase (PRCP) Antibody

PRCP Antibody is a Rabbit Polyclonal antibody against PRCP. The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Target	Prolylcarboxypeptidase (PRCP)
Clonality	Polyclonal
Reactivity	Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/1000 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 407-496 of human PRCP.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P42785 (UniProt, ExPASy)
UniProt Secondary AC	A8MU24, B2R7B7, B3KRK5, B5BU34
UniProt Entry Name	PCP_HUMAN
Gene Symbol	PRCP
GeneID	5547
NCBI Accession	NP_005031.1
KEGG	hsa:5547
String	9606.ENSP00000377055
Molecular Weight	Calculated MW: 56 kDa Observed MW: 56 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Prolylcarboxypeptidase (PRCP)

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