Putative Histone-Lysine N-Methyltransferase PRDM6 (PRDM6) Antibody
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Catalogue No: abx028039
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(Size: 80 µl)
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Datasheet SDS
Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (By similarity).
Research Articles on Putative Histone-Lysine N-Methyltransferase PRDM6 (PRDM6)
| Target | Putative Histone-Lysine N-Methyltransferase PRDM6 (PRDM6) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 44-72 amino acids from the N-terminal region of human PRDM6. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q9NQX0 (UniProt, ExPASy) |
| UniProt Secondary AC | B5MCJ4, Q9NQW9 |
| UniProt Entry Name | PRDM6_HUMAN |
| Gene Symbol | PRDM6 |
| String | 9606.ENSP00000384725 |
| Molecular Weight | Calculated MW: 64.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Concentration | 0.45 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |