Perforin 1 (PRF1) Antibody

Catalogue No: abx000550
Price: £120.00
(Size: 20 µl)
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PRF1 Antibody is a Rabbit Polyclonal antibody against PRF1. The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

Target Perforin 1 (PRF1)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 280-555 of human Perforin.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P14222 (UniProt, ExPASy)
UniProt Secondary AC B2R6X4, Q59F57, Q86WX7
UniProt Entry Name PERF_HUMAN
Gene Symbol PRF1
GeneID 5551
OMIM 170280
NCBI Accession NP_001076585.1
HGNC 9360
KEGG hsa:5551
Ensembl ENSG00000180644
String 9606.ENSP00000398568
Molecular Weight Calculated MW: 61 kDa
Observed MW: 70 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration 2.11 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Perforin 1 (PRF1)

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