Perforin 1 (PRF1) Antibody

PRF1 Antibody is a Rabbit Polyclonal antibody against PRF1. The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

Target	Perforin 1 (PRF1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 280-555 of human Perforin.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P14222 (UniProt, ExPASy)
UniProt Secondary AC	B2R6X4, Q59F57, Q86WX7
UniProt Entry Name	PERF_HUMAN
Gene Symbol	PRF1
GeneID	5551
OMIM	170280
NCBI Accession	NP_001076585.1
HGNC	9360
KEGG	hsa:5551
Ensembl	ENSG00000180644
String	9606.ENSP00000398568
Molecular Weight	Calculated MW: 61 kDa Observed MW: 70 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	2.11 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Perforin 1 (PRF1)

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