Perforin 1 (PRF1) Antibody
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Catalogue No: abx000550
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US$348.00
(Size: 60 µl)
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Datasheet SDS
PRF1 Antibody is a Rabbit Polyclonal antibody against PRF1. The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.
Research Articles on Perforin 1 (PRF1)
| Target | Perforin 1 (PRF1) |
| Research Area | Immunology |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human Perforin |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P14222 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R6X4, Q59F57, Q86WX7 |
| UniProt Entry Name | PERF_HUMAN |
| Gene Symbol | PRF1 |
| GeneID | 5551 |
| OMIM | 170280 |
| NCBI Accession | NP_001076585.1 |
| HGNC | 9360 |
| KEGG | hsa:5551 |
| Ensembl | ENSG00000180644 |
| String | 9606.ENSP00000398568 |
| Molecular Weight | Calculated MW: 61 kDa Observed MW: 70 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
