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Perforin 1 (PRF1) Antibody

Catalogue No: abx000550
Price: £120.00
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Perforin 1 (PRF1) Antibody

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PRF1 Antibody is a Rabbit Polyclonal antibody against PRF1. The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

Target PRF1
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human PRF1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P14222 (UniProt, ExPASy)
UniProt Secondary AC B2R6X4, Q59F57, Q86WX7
UniProt Entry Name PERF_HUMAN
Gene Symbol PRF1
GeneID 5551
String 9606.ENSP00000398568
Molecular Weight Calculated MW: 61 kDa
Observed MW: 66 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Perforin 1 (PRF1) Antibody

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