Protein Kinase, cAMP Dependent Catalytic Beta (PRKACB) Antibody

PRKACB Antibody is a Rabbit Polyclonal antibody against PRKACB. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed.

Target	Protein Kinase, cAMP Dependent Catalytic Beta (PRKACB)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 250-351 of human PKA C-beta (PRKACB).
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P22694 (UniProt, ExPASy)
UniProt Entry Name	KAPCB_HUMAN
Gene Symbol	PRKACB
GeneID	5567
NCBI Accession	NP_002722.1
KEGG	hsa:5567
String	9606.ENSP00000359719
Molecular Weight	Calculated MW: 41 kDa Observed MW: 46 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Protein Kinase, cAMP Dependent Catalytic Beta (PRKACB)

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