CAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit (PRKAR1A) Antibody

PRKAR1A Antibody is a Rabbit Polyclonal antibody against PRKAR1A. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed.

Target	CAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit (PRKAR1A)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human PRKAR1A.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P10644 (UniProt, ExPASy)
UniProt Secondary AC	K7ER48, Q567S7
UniProt Entry Name	KAP0_HUMAN
Gene Symbol	PRKAR1A
GeneID	5573
NCBI Accession	NP_002725.1
KEGG	hsa:5573
String	9606.ENSP00000376475
Molecular Weight	Calculated MW: 43 kDa Observed MW: 48 kDa
Buffer	PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on CAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit (PRKAR1A)

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