CAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit (PRKAR1A) Antibody

Catalogue No: abx000892
Price: £120.00
(Size: 20 µl)
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CAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit (PRKAR1A) Antibody CAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit (PRKAR1A) Antibody

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PRKAR1A Antibody is a Rabbit Polyclonal antibody against PRKAR1A. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed.

Target CAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit (PRKAR1A)
Clonality Polyclonal
Reactivity Human
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human PRKAR1A.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P10644 (UniProt, ExPASy)
UniProt Secondary AC K7ER48, Q567S7
UniProt Entry Name KAP0_HUMAN
Gene Symbol PRKAR1A
GeneID 5573
KEGG hsa:5573
String 9606.ENSP00000376475
Molecular Weight Calculated MW: 38 kDa, 42 kDa
Observed MW: 45 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on CAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit (PRKAR1A) Antibody

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