Protein Kinase cAMP-Dependent Type II Regulatory Subunit Beta (PRKAR2B) Antibody

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq].

Target	Protein Kinase cAMP-Dependent Type II Regulatory Subunit Beta (PRKAR2B)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 119-147 amino acids from the Central region of human PRKAR2B.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P31323 (UniProt, ExPASy)
UniProt Secondary AC	A4D0R9
UniProt Entry Name	KAP3_HUMAN
Gene Symbol	PRKAR2B
KEGG	hsa:5577
String	9606.ENSP00000265717
Molecular Weight	Calculated MW: 46.3 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat and Cow PRKAR2B.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Protein Kinase cAMP-Dependent Type II Regulatory Subunit Beta (PRKAR2B)

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