Protein Kinase, CGMP Dependent Type I (PRKG1) Antibody

Catalogue No: abx002002
Price: £120.00
(Size: 20 µl)
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Protein Kinase, CGMP Dependent Type I (PRKG1) Antibody Protein Kinase, CGMP Dependent Type I (PRKG1) Antibody

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PRKG1 Antibody is a Rabbit Polyclonal antibody against PRKG1. Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.

Target PRKG1
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PRKG1 (NP_006249.1).
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q13976 (UniProt, ExPASy)
UniProt Secondary AC A5YM56, B3KSF3, E2PU10, P14619, Q5JP05, Q5JSJ6, Q6P5T7
Gene Symbol PRKG1
GeneID 5592
Molecular Weight Calculated MW: 44 kDa, 76 kDa, 77 kDa
Observed MW: 65 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration 1.85 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Protein Kinase, CGMP Dependent Type I (PRKG1) Antibody

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