Protein Kinase, CGMP Dependent Type I (PRKG1) Antibody

PRKG1 Antibody is a Rabbit Polyclonal antibody against PRKG1. Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.

Target	Protein Kinase, CGMP Dependent Type I (PRKG1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PRKG1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13976 (UniProt, ExPASy)
UniProt Secondary AC	A5YM56, B3KSF3, E2PU10, P14619, Q5JP05, Q5JSJ6, Q6P5T7
Gene Symbol	PRKG1
GeneID	5592
NCBI Accession	NP_006249.1
Molecular Weight	Calculated MW: 76 kDa Observed MW: 65 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	1.85 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Protein Kinase, CGMP Dependent Type I (PRKG1)

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