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Prion Protein (PRNP) Antibody

Catalogue No: abx002019
Price: £120.00
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Prion Protein (PRNP) Antibody Prion Protein (PRNP) Antibody Prion Protein (PRNP) Antibody

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PRNP Antibody is a Rabbit Polyclonal antibody against PRNP. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.

Target Prion Protein (PRNP)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human PRNP.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P04156 (UniProt, ExPASy)
UniProt Entry Name PRIO_HUMAN
Gene Symbol PRNP
GeneID 5621
KEGG hsa:5621
String 9606.ENSP00000368752
Molecular Weight Calculated MW: 8 kDa, 26 kDa, 27 kDa
Observed MW: 31 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Prion Protein (PRNP) Antibody

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