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Human 26S Proteasome Regulatory Subunit 4 (PSMC1) Protein
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Catalogue No: abx168284
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US$261.00
(Size: 10 µg)
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Datasheet SDS
Human 26S Proteasome Regulatory Subunit 4 (PSMC1) Protein is a recombinant Human protein expressed in E. coli. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder.
Research Articles on 26S Proteasome Regulatory Subunit 4 (PSMC1)
| Target | 26S Proteasome Regulatory Subunit 4 (PSMC1) |
| Origin | Human |
| Expression | Recombinant |
| Tested Applications | WB, SDS-PAGE |
| Host | E. coli |
| Conjugation | Unconjugated |
| Form | Lyophilized |
| Activity | Not tested |
| Purity | > 95% |
| Reconstitution | To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P62191 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DR63, P49014, Q03527, Q6IAW0, Q6NW36, Q96AZ3 |
| UniProt Entry Name | PRS4_HUMAN |
| Gene Symbol | PSMC1 |
| GeneID | 5700 |
| OMIM | 602706 |
| NCBI Accession | NP_001317141.1 NM_001330212.1 NP_002793.2 NM_002802.2 |
| HGNC | 9547 |
| KEGG | hsa:5700 |
| Ensembl | ENSG00000100764 |
| String | 9606.ENSP00000261303 |
| Molecular Weight | Calculated MW: 53.9 kDa |
| Sequence Fragment | Met1-Leu440 |
| Tag | N-terminal His tag |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Concentration | Prior to lyophilization: 200 µg/ml |
| Availability | Shipped within 5-7 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |