Human 26S Proteasome Non-ATPase Regulatory Subunit 11 (PSMD11) Protein

26S Proteasome Non-ATPase Regulatory Subunit 11 (PSMD11) is a recombinant enzyme. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene.

Target	26S Proteasome Non-ATPase Regulatory Subunit 11 (PSMD11)
Origin	Human
Expression	Recombinant
Tested Applications	SDS-PAGE
Host	E. coli
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Form	Liquid
Purity	> 85% (SDS-PAGE)
Storage	Store at 4 °C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O00231 (UniProt, ExPASy)
UniProt Secondary AC	A8K3I7, E1P663, O00495, Q53FT5
UniProt Entry Name	PSD11_HUMAN
Gene Symbol	PSMD11
GeneID	5717
OMIM	604449
NCBI Accession	NP_001257411.1 NM_001270482.1 [O00231-1] NP_002806.2 NM_002815.3 [O00231-1]
HGNC	9556
KEGG	hsa:5717
Ensembl	ENSG00000108671
String	9606.ENSP00000261712
Sequence	MGSSHHHHHH SSGLVPRGSH MAAAAVVEFQ RAQSLLSTDR EASIDILHSI VKRDIQENDE EAVQVKEQSI LELGSLLAKT GQAAELGGLL KYVRPFLNSI SKAKAARLVR SLLDLFLDME AATGQEVELC LECIEWAKSE KRTFLRQALE ARLVSLYFDT KRYQEALHLG SQLLRELKKM DDKALLVEVQ LLESKTYHAL SNLPKARAAL TSARTTANAI YCPPKLQATL DMQSGIIHAA EEKDWKTAYS YFYEAFEGYD SIDSPKAITS LKYMLLCKIM LNTPEDVQAL VSGKLALRYA GRQTEALKCV AQASKNRSLA DFEKALTDYR AELRDDPIIS THLAKLYDNL LEQNLIRVIE PFSRVQIEHI SSLIKLSKAD VERKLSQMIL DKKFHGILDQ GEGVLIIFDE PPVDKTYEAA LETIQNMSKV VDSLYNKAKK LT.
Activity	Not tested
Availability	Shipped within 5-10 working days.
Note	This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

Research Articles on 26S Proteasome Non-ATPase Regulatory Subunit 11 (PSMD11)

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