Human 26S Proteasome Non-ATPase Regulatory Subunit 9 (PSMD9) Protein

Proteasome 26S Subunit, Non-ATPase 9 is a recombinant enzyme. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene.

Target	26S Proteasome Non-ATPase Regulatory Subunit 9 (PSMD9)
Origin	Human
Expression	Recombinant
Tested Applications	SDS-PAGE
Host	E. coli
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Form	Liquid
Purity	> 90% (SDS-PAGE)
Storage	Store at 4 °C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O00233 (UniProt, ExPASy)
UniProt Secondary AC	B2RD35, G3V1Q6, Q9BQ42
UniProt Entry Name	PSMD9_HUMAN
Gene Symbol	PSMD9
GeneID	5715
OMIM	603146
NCBI Accession	NP_001248329.1 NM_001261400.2 [O00233-3] NP_002804.2 NM_002813.6 [O00233-1]
KEGG	hsa:5715
Ensembl	ENSG00000110801
String	9606.ENSP00000440485
Sequence	MGSSHHHHHH SSGLVPRGSH MGSMSDEEAR QSGGSSQAGV VTVSDVQELM RRKEEIEAQI KANYDVLESQ KGIGMNEPLV DCEGYPRSDV DLYQVRTARH NIICLQNDHK AVMKQVEEAL HQLHARDKEK QARDMAEAHK EAMSRKLGQS ESQGPPRAFA KVNSISPGSP ASIAGLQVDD EIVEFGSVNT QNFQSLHNIG SVVQHSEGKP LNVTVIRRGE KHQLRLVPTR WAGKGLLGCN IIPLQR.
Activity	Not tested
Availability	Shipped within 5-10 working days.
Note	This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

Research Articles on 26S Proteasome Non-ATPase Regulatory Subunit 9 (PSMD9)

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