Human Proteasome Subunit Beta Type 3 (PSMB3) Protein
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Catalogue No: abx073543
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(Size: 5 µg)
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Datasheet SDS
Proteasome Subunit Beta Type 3 (PSMB3) is a recombinant enzyme. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12.
Research Articles on Proteasome Subunit Beta Type 3 (PSMB3)
| Target | Proteasome Subunit Beta Type 3 (PSMB3) |
| Research Area | Enzymes and Kinases |
| Origin | Human |
| Expression | Recombinant |
| Tested Applications | SDS-PAGE |
| Host | E. coli |
| Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
| Form | Liquid |
| Activity | Not tested |
| Purity | > 90% (SDS-PAGE) |
| Purification | Purified by proprietary chromatographic techniques. |
| Storage | Store at -20°C for long term storage or at 4°C for up to 1 month. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P49720 (UniProt, ExPASy) |
| UniProt Secondary AC | P31147, Q0P6J7, Q96E27 |
| UniProt Entry Name | PSB3_HUMAN |
| Gene Symbol | PSMB3 |
| GeneID | 5691 |
| OMIM | 602176 |
| HGNC | 9540 |
| KEGG | hsa:5691 |
| Ensembl | ENSG00000277791 |
| String | 9606.ENSP00000483688 |
| Molecular Weight | 25.1 kDa |
| Sequence Fragment | 1-205 AA. |
| Sequence | MGSSHHHHHH SSGLVPRGSH MSIMSYNGGA VMAMKGKNCV AIAADRRFGI QAQMVTTDFQ KIFPMGDRLY IGLAGLATDV QTVAQRLKFR LNLYELKEGR QIKPYTLMSM VANLLYEKRF GPYYTEPVIA GLDPKTFKPF ICSLDLIGCP MVTDDFVVSG TCAEQMYGMC ESLWEPNMDP DHLFETISQA MLNAVDRDAV SGMGVIVHII EKDKITTRTL KARMD |
| Buffer | 20 mM Tris-HCl buffer, pH 8.0, containing 200 mM NaCl, 1 mM DTT and 50% glycerol. |
| Concentration | 0.25 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |