26S Proteasome Regulatory Subunit 7 (PSMC2) Antibody

Catalogue No: abx018097
Price: £240.00
(Size: 100 µg)

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Datasheet SDS
26S Proteasome Regulatory Subunit 7 (PSMC2) Antibody is a Mouse Monoclonal antibody against 26S Proteasome Regulatory Subunit 7 (PSMC2). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Target 26S Proteasome Regulatory Subunit 7 (PSMC2)
Clonality Monoclonal
Reactivity Human
Tested Applications ELISA, WB
Host Mouse
Recommended dilutions Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Isotype IgG1
Form Liquid
Purification Purified from ascites by Protein A chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P35998 (UniProt, ExPASy)
UniProt Secondary AC A4D0Q1, B7Z5E2, Q3LIA5, Q9UDI3
UniProt Entry Name PRS7_HUMAN
Gene Symbol PSMC2
GeneID 5701
OMIM 154365
NCBI Accession NM_002803
HGNC 9548
KEGG hsa:5701
Ensembl ENSG00000161057
String 9606.ENSP00000391211
Buffer Citrate-Tris-HCl, pH 7.0, with 0.02% Proclin-300.
Concentration 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on 26S Proteasome Regulatory Subunit 7 (PSMC2)

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