protein Tyrosine Phosphatase 1B (PTP1B) Antibody

protein Tyrosine Phosphatase 1B (PTP1B) Antibody is a Rabbit Polyclonal antibody for the detection of PTP1B.

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.

Target	protein Tyrosine Phosphatase 1B (PTP1B)
Clonality	Polyclonal
Reactivity	Human, Rat
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	protein tyrosine phosphatase, non-receptor type 1
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P18031 (UniProt, ExPASy)
UniProt Secondary AC	Q5TGD8, Q9BQV9, Q9NQQ4
UniProt Entry Name	PTN1_HUMAN
Gene Symbol	PTPN1
GeneID	5770
OMIM	176885
HGNC	9642
KEGG	hsa:5770
Ensembl	ENSG00000196396
String	9606.ENSP00000360683
Molecular Weight	Observed MW: 50 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on protein Tyrosine Phosphatase 1B (PTP1B)

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