Vitamin K-Dependent Protein Z (PROZ) Antibody

PROZ protein Z, vitamin K-dependent plasma glycoprotein.It is 62 kDa large and 396 amino acids long.It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain.It lacks the serine residue that would make it catalytically active as a serine protease.It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots.It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy.It is a glycoprotein.Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C.The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces.The main role of protein Z appears to be the degradation of factor Xa.This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z.Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z.In some studies, deficiency states have been associated with a propensity to thrombosis.Others, however, link it to bleeding tendency; there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.

Target	Vitamin K-Dependent Protein Z (PROZ)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of PROZ expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P22891 (UniProt, ExPASy)
UniProt Secondary AC	A6NMB4, Q15213, Q5JVF5, Q5JVF6
UniProt Entry Name	PROZ_HUMAN
Gene Symbol	PROZ
GeneID	8858
OMIM	176895
HGNC	9460
KEGG	hsa:8858
Ensembl	ENSG00000126231
String	9606.ENSP00000344458
Molecular Weight	45 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Vitamin K-Dependent Protein Z (PROZ)

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