Presenilin 1 (PSEN1) Antibody

Catalogue No: abx001799
Price: £120.00
(Size: 20 µl)
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PSEN1 Antibody is a Rabbit Polyclonal antibody against PSEN1. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Target PSEN1
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human PSEN1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P49768 (UniProt, ExPASy)
UniProt Secondary AC B2R6D3, O95465, Q14762, Q15719, Q15720, Q96P33, Q9UIF0
UniProt Entry Name PSN1_HUMAN
Gene Symbol PSEN1
GeneID 5663
KEGG hsa:5663
String 9606.ENSP00000326366
Molecular Weight Calculated MW: 21 kDa, 42 kDa, 46 kDa, 48 kDa, 52 kDa
Observed MW: 53 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on PSEN1

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