26S Proteasome Regulatory Subunit 4 (PSMC1) Antibody

Catalogue No: abx114740
Price: £275.00
(Size: 50 µl)

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Datasheet SDS
26S Proteasome Regulatory Subunit 4 (PSMC1) Antibody is a Rabbit Polyclonal antibody against 26S Proteasome Regulatory Subunit 4 (PSMC1). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder.

Target 26S Proteasome Regulatory Subunit 4 (PSMC1)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications ELISA, WB
Host Rabbit
Recommended dilutions Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Human PSMC1.
Isotype IgG
Form Liquid
Purification Antigen Affinity Chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P62191 (UniProt, ExPASy)
UniProt Secondary AC B4DR63, P49014, Q03527, Q6IAW0, Q6NW36, Q96AZ3
UniProt Entry Name PRS4_HUMAN
Gene Symbol PSMC1
GeneID 5700
OMIM 602706
NCBI Accession NP_001317141.1 NM_001330212.1 NP_002793.2 NM_002802.2
HGNC 9547
KEGG hsa:5700
Ensembl ENSG00000100764
String 9606.ENSP00000261303
Buffer PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on 26S Proteasome Regulatory Subunit 4 (PSMC1)

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