26S Proteasome Regulatory Subunit 4 (PSMC1) Antibody

Rabbit Polyclonal against the 26S Proteasome Regulatory Subunit 4 (PSMC1) protein. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder.

Target	26S Proteasome Regulatory Subunit 4 (PSMC1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fragment corresponding to 3-169 AA of human PSMC1.
Isotype	IgG
Form	Lyophilized
Purification	Purified by antigen affinity column chromatography.
Reconstitution	Reconstitute in 100 µl of sterile distilled H2O with 50% glycerol.
Storage	Store at -20 °C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P62191 (UniProt, ExPASy)
UniProt Secondary AC	B4DR63, P49014, Q03527, Q6IAW0, Q6NW36, Q96AZ3
UniProt Entry Name	PRS4_HUMAN
Gene Symbol	PSMC1
GeneID	5700
OMIM	602706
NCBI Accession	NP_001317141.1 NM_001330212.1 NP_002793.2 NM_002802.2
HGNC	9547
KEGG	hsa:5700
Ensembl	ENSG00000100764
String	9606.ENSP00000261303
Molecular Weight	Observed MW: 60 kDa
Buffer	Prior to lyophilization: 1% BSA and 0.02% NaN3.
Specificity	Predicted to react with Mouse and Rat PSMC1.
Concentration	Lyophilized form: Not applicable. After reconstitution: 1 mg/ml.
Availability	Shipped within 7-15 working days.
Note	This product is for research use only.

Research Articles on 26S Proteasome Regulatory Subunit 4 (PSMC1)

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