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26S Proteasome Regulatory Subunit 4 (PSMC1) Antibody
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Catalogue No: abx236877
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US$420.50
(Size: 100 µg)
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Datasheet SDS
26S Proteasome Regulatory Subunit 4 (PSMC1) Antibody is a Rabbit Polyclonal against 26S Proteasome Regulatory Subunit 4 (PSMC1). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder.
Research Articles on 26S Proteasome Regulatory Subunit 4 (PSMC1)
| Target | 26S Proteasome Regulatory Subunit 4 (PSMC1) |
| Research Area | Enzymes and Kinases |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | proteasome (prosome, macropain) 26S subunit, ATPase, 1 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P62191 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DR63, P49014, Q03527, Q6IAW0, Q6NW36, Q96AZ3 |
| UniProt Entry Name | PRS4_HUMAN |
| Gene Symbol | PSMC1 |
| GeneID | 5700 |
| OMIM | 602706 |
| NCBI Accession | NP_001317141.1 NM_001330212.1 NP_002793.2 NM_002802.2 |
| HGNC | 9547 |
| KEGG | hsa:5700 |
| Ensembl | ENSG00000100764 |
| String | 9606.ENSP00000261303 |
| Molecular Weight | Observed MW: 55 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |