26S Proteasome Regulatory Subunit 6A (PSMC3) Antibody (FITC)

26S Proteasome Regulatory Subunit 6A (PSMC3) Antibody (FITC) is a Rabbit Polyclonal against 26S Proteasome Regulatory Subunit 6A (PSMC3) conjugated to FITC. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.

Target	26S Proteasome Regulatory Subunit 6A (PSMC3)
Clonality	Polyclonal
Reactivity	Human
Host	Rabbit
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Conjugation	FITC
Excitation/Emission	499/515
Laser Line	488
Immunogen	Recombinant human 26S protease regulatory subunit 6A protein (1-300AA).
Isotype	IgG
Form	Liquid
Purity	> 95%
Purification	Purified by Protein G.
Storage	Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P17980 (UniProt, ExPASy)
UniProt Secondary AC	B2R8V1, Q3B757, Q3B865, Q53HU5, Q6GPG8, Q6IBS1, Q96HD3
UniProt Entry Name	PRS6A_HUMAN
Gene Symbol	PSMC3
GeneID	5702
OMIM	186852
NCBI Accession	NM_002804
HGNC	9549
KEGG	hsa:5702
Ensembl	ENSG00000165916
String	9606.ENSP00000481029
Buffer	0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 26S Proteasome Regulatory Subunit 6A (PSMC3)

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