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26S Proteasome Regulatory Subunit 6A (PSMC3) Antibody
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Catalogue No: abx038460
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US$398.75
(Size: 100 µg)
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Datasheet SDS
Rabbit Polyclonal against the 26S Proteasome Regulatory Subunit 6A (PSMC3) protein. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.
Research Articles on 26S Proteasome Regulatory Subunit 6A (PSMC3)
| Target | 26S Proteasome Regulatory Subunit 6A (PSMC3) |
| Research Area | Enzymes and Kinases |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A peptide corresponding to middle region of human PSMC3 protein. |
| Isotype | IgG |
| Form | Lyophilized |
| Purification | Purified by antigen affinity column chromatography. |
| Reconstitution | Reconstitute in 100 µl of sterile distilled H2O with 50% glycerol. |
| Storage | Store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P17980 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R8V1, Q3B757, Q3B865, Q53HU5, Q6GPG8, Q6IBS1, Q96HD3 |
| UniProt Entry Name | PRS6A_HUMAN |
| Gene Symbol | PSMC3 |
| GeneID | 5702 |
| OMIM | 186852 |
| NCBI Accession | NM_002804 |
| HGNC | 9549 |
| KEGG | hsa:5702 |
| Ensembl | ENSG00000165916 |
| String | 9606.ENSP00000481029 |
| Molecular Weight | Observed MW: 49 kDa |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Concentration | Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Availability | Shipped within 7-15 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |