26S Proteasome Regulatory Subunit 6A (PSMC3) Antibody

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Catalogue No: abx103499
Price: US$319.00
(Size: 100 µl)

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Datasheet SDS
Polyclonal Antibody to 26S Proteasome Regulatory Subunit 6A (PSMC3). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.

Target 26S Proteasome Regulatory Subunit 6A (PSMC3)
Clonality Polyclonal
Reactivity Human
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1-5 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen PSMC3 (Asn2-Ala439)
Form Liquid
Purification Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P17980 (UniProt, ExPASy)
UniProt Secondary AC B2R8V1, Q3B757, Q3B865, Q53HU5, Q6GPG8, Q6IBS1, Q96HD3
UniProt Entry Name PRS6A_HUMAN
Gene Symbol PSMC3
GeneID 5702
OMIM 186852
NCBI Accession NM_002804
HGNC 9549
KEGG hsa:5702
Ensembl ENSG00000165916
String 9606.ENSP00000481029
Buffer 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability Shipped within 5-7 working days.
Note This product is for research use only.
Research Articles on 26S Proteasome Regulatory Subunit 6A (PSMC3)


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