26S Proteasome Regulatory Subunit 6B (PSMC4) Antibody
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Catalogue No: abx122052
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US$398.75
(Size: 100 µg)
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Datasheet SDS
Rabbit Polyclonal against the 26S Proteasome Regulatory Subunit 6B (PSMC4) protein. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Research Articles on 26S Proteasome Regulatory Subunit 6B (PSMC4)
| Target | 26S Proteasome Regulatory Subunit 6B (PSMC4) |
| Research Area | Enzymes and Kinases |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fragment corresponding to 24-221 AA of human PSMC4. |
| Isotype | IgG |
| Form | Lyophilized |
| Purification | Purified by antigen affinity column chromatography. |
| Reconstitution | Reconstitute in 100 µl of sterile distilled H2O with 50% glycerol. |
| Storage | Store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P43689 (UniProt, ExPASy) |
| UniProt Secondary AC | Q96FV5, Q9UBM3, Q9UEX6 |
| UniProt Entry Name | PRS6B_HUMAN |
| Gene Symbol | PSMC4 |
| GeneID | 5704 |
| OMIM | 602707 |
| NCBI Accession | NP_006494.1 NM_006503.3 NP_694546.1 NM_153001.2 |
| HGNC | 9551 |
| Ensembl | ENSG00000013275 |
| String | 9606.ENSP00000157812 |
| Molecular Weight | Observed MW: 47 kDa |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Specificity | Predicted to react with Mouse and Rat PSMC4. |
| Concentration | Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Availability | Shipped within 7-15 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |