26S Proteasome Regulatory Subunit 6B (PSMC4) Antibody

Catalogue No: abx001948
Price: £120.00
(Size: 20 µl)
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26S Proteasome Regulatory Subunit 6B (PSMC4) Antibody is a Rabbit Polyclonal antibody against 26S Proteasome Regulatory Subunit 6B (PSMC4). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Target 26S Proteasome Regulatory Subunit 6B (PSMC4)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human PSMC4.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P43686 (UniProt, ExPASy)
UniProt Secondary AC Q96FV5, Q9UBM3, Q9UEX3
UniProt Entry Name PRS6B_HUMAN
Gene Symbol PSMC4
GeneID 5704
OMIM 602707
NCBI Accession NP_006494.1 NM_006503.3 NP_694546.1 NM_153001.2
HGNC 9551
KEGG hsa:5704
Ensembl ENSG00000013275
String 9606.ENSP00000157812
Molecular Weight Calculated MW: 43 kDa, 47 kDa
Observed MW: 48 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on 26S Proteasome Regulatory Subunit 6B (PSMC4)

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