26S Proteasome Regulatory Subunit 6B (PSMC4) Antibody

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Catalogue No: abx236880
Price: US$406.00
(Size: 100 µg)

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Datasheet SDS
26S Proteasome Regulatory Subunit 6B (PSMC4) Antibody is a Rabbit Polyclonal against 26S Proteasome Regulatory Subunit 6B (PSMC4). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Target 26S Proteasome Regulatory Subunit 6B (PSMC4)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications ELISA, WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/20 - 1/200, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen proteasome(prosome, macropain) 26S subunit, ATPase, 4
Isotype IgG
Form Liquid
Purity ≥ 95% (SDS-PAGE)
Purification Purified by immunogen affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity 12 months.
UniProt Primary AC P43691 (UniProt, ExPASy)
UniProt Secondary AC Q96FV5, Q9UBM3, Q9UEX8
UniProt Entry Name PRS6B_HUMAN
Gene Symbol PSMC4
GeneID 5704
OMIM 602707
NCBI Accession NP_006494.1 NM_006503.3 NP_694546.1 NM_153001.2
HGNC 9551
KEGG gga:396392
Ensembl ENSG00000013275
String 9606.ENSP00000157812
Molecular Weight Observed MW: 47 kDa
Buffer PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration 2 mg/ml
Availability Shipped within 5-12 working days.
Note This product is for research use only.
Research Articles on 26S Proteasome Regulatory Subunit 6B (PSMC4)


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