26S Proteasome Regulatory Subunit 8 (PSMC5) Antibody
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Catalogue No: abx001295
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US$348.00
(Size: 60 µl)
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Datasheet SDS
PSMC5 Antibody is a Rabbit Polyclonal antibody against PSMC5. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
Research Articles on 26S Proteasome Regulatory Subunit 8 (PSMC5)
| Target | 26S Proteasome Regulatory Subunit 8 (PSMC5) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human PSMC5 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P62195 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K3Z3, A8K763, O35051, O43208, P47210, P52915, P52916 |
| UniProt Entry Name | PRS8_HUMAN |
| Gene Symbol | PSMC5 |
| GeneID | 5705 |
| NCBI Accession | NP_002796.4 |
| KEGG | hsa:5705 |
| String | 9606.ENSP00000310572 |
| Molecular Weight | Calculated MW: 44 kDa/45 kDa Observed MW: 45 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
